p-ISSN: 1454-7848
e-ISSN: 2068-7176



Introduction: There is an increase in incidence of autism among children. The development of comprehensive therapeutic approaches and techniques for the recovery of those affected becomes a necessity. Moreover, evaluating the progress and the results of the therapeutic interventions, as well as identifying the clinical variables that can influence the quality of the response to therapy are just as important. Objectives: This paper aims to analyze the progress and results of an early intensive behavioral intervention. Methods: The current study was conducted in 116 children aged between 2 and 5 years old with an autism diagnosis. The developmental domains are evaluated with the ADOS- G test. We analyzed the variation of ADOS score consequently to applied therapy, as well as the influence of comorbidities such as ADHD or intellectual disability on the patient's progress. Results: Our results show that after 2 years of EIBI, the ADOS-G total score decreased on average with 2,98 points, and for 14 children this score was below the diagnostic threshold. Comorbidities did not have an influence on the progress. These results certify the efficiency of EIBI therapies and encourages the start of a therapeutic program independent of the severity of the symptoms or associated pathologies.

Autism affects an increasing number of people all around the world. In 1997 in Great Britain, the prevalence was estimated at 7,2/1000 children between 3 and 15 years old, and in 2006, one study on children aged 0-15 years old reported a prevalence of 44,2/10000 (1). In 2014, in the United States of America, the Center for Disease Control reported a prevalence of 1/68 children aged up to 13 years old (2). It is estimated that 1% of the planet’s population is affected by autism (3).
The increasing global incidence of this disorder incites a great interest among professionals, who are looking for causes and more precise methods of symptom identification, as well as treatment solutions, through psychological interventions or medication. Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in social interaction, verbal and non-verbal communication and the presence of restrictive and repetitive behaviors (4). In reality, the symptoms of autism are very rarely confined to those mentioned above, as it usually is associated with other comorbid disorders. There are many more domains that are affected, and they usually are correlated. In one study, 55% of children with ASD from the sample had an IQ below 70 (intellectual disability), 17% had an IQ between 70 and 85, 28% had an average IQ, and 3% had an IQ that was above average (5). It is estimated that eating disorders affect 70-90% of children on the autism spectrum (6). Another study shows that 52% of the children participating in a study of facial recognition met the criteria for a comorbid diagnosis of ADHD (7). The impairment in these clinical and psychological domains in children with ASD affect identification, evaluation and intervention. Recently, a series of specific behavioral interventions have been developed to improve cognitive, social, self-help, language and communication, emotional processing and self-control domains (8). A series of studies researched the efficacy of numerous therapies and interventions in public or private therapy centers around the world. They show that early intensive interventions based on applied behavior analysis significantly improve the lives of children with autism, especially when it comes to cognitive, communication and repetitive behavior domains (9). This type of intervention involves more than
15 hours per week of direct work with the child in one-to- one sessions, targeting many areas of development from very young ages- 1,6 or 2 years old. Some interventions address specific symptoms – reducing anxiety or disruptive behaviors- others focus on developing language and communication skills or direct interaction and socialization. In the literature the most efficient interventions for children with autism are: Applied Behavior Analysis, Incidental Teaching, Pivotal Response Treatment, Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH). These are called EIBI (Early Intensive Behavior Intervention) (10).
In trying to understand why some children improve and others do not and what are the important factors for the progress in therapy, the following variables have been measured : age, severity of ASD symptoms, IQ, comorbid disorders, and the adaptive functioning (11)(12). Some researchers report that the symptom severity and IQ influence the adaptive functioning at different ages, which is a predictive factor of independency as a young adult and of therapy success (13).
In this paper, we aim to analyze the progress of a group of children, shown through standard psychological testing specific for ASD , while accounting for the clinical variables that have been shown to have a major influence on the efficacy of therapy for children with autism spectrum disorders.
The research was conducted between 2014-2017 on a sample of 116 children aged between 2 and 5 years old, diagnosed with autism by a specialist in Child Psychiatry in the public healthcare system. Moreover, o t h e r c o m o r b i d i t i e s w e r e a c c o u n t e d – A D H D , hyperkinetic disorder, intellectual disability – IQ lower than 70.
The ASD symptoms and their severity were evaluated with ADOS-G Modules 1 and 2 (Lord, Rutter, DiLavore, Risi, 1999) at intake and after 2 years of intensive therapeutic intervention. ADOS is a semi- structured instrument that can be used to evaluate autism symptoms, from non-verbal children to verbally fluent adults. ADOS is based on the operationalization of d i a g n o s t i c c r i t e r i a f o r a u t i s m a n d p e r v a s i v e developmental disorders from DSM-IV/ICD-10. Scores for social interaction, communication and repetitive behaviors, as well as total scores were calculated and used as a measure of the severity of ASD symptoms. Based on these, statistic analysis was carried out to calculate the progress of each child after 2 years of therapy, as well as the means, standard deviations, correlation coefficients, etc.
Children received 15 h/week of early intensive behavioral therapy (EIBI) based on modern ABA and other approaches recommended by scientific evidence as being effective in children with autism : Pivotal Response treatment, Incidental teaching, Early Start Denver Model. The one-to-one intervention was held in a controlled environment, with the same coordinator and with a child centered curriculum, including all the specific developmental domains.
After 2 years of EIBI therapy, the statistical analysis of ADOS-G scores on the entire sample showed a mean decrease of 2,98 points in the total score, with a standard deviation of 1,588. From the sample, 97,4% of children had the ADOS total scores decreased, while 1,72% of scores remained the same and 0,86% (1 child) had an increase in the total ADOS scores (a total score of 8 at the initial evaluation and a total score of 9 at the 2 year evaluation). For 14 of the children, the decrease was so significant that after the reevaluation, they did not meet the criteria for the autism spectrum anymore. The statistical analysis of the ADOS total score for the complete sample is shown in Fig. 1.

The children were split into two groups – according to their scores and the severity of their symptoms- one group that fit the criteria for the autism spectrum disorder and one group that fit the diagnostic criteria according to DSM IV. There were 37 children in the ASD group, with a mean decrease in the ADOS total score of 2,81 and a standard deviation of 1,561. In the autism group, there were 79 children, with a mean decrease in the total score of 3,06 points.
The total scores of the two groups according to the severity of ASD symptoms and the frequency of their decrease is shown in Fig. 2 and Fig. 3, respectively.
A variable that is frequently found in the literature as a factor that influences the child’s progress and therapeutic success is the presence comorbidities. The most common comorbid conditions are ADHD and hyperkinetic disorder, which is true for our sample as well. Fifty four (46,5%) children had this type of comorbidity. We compared the group with these disorders to the group that did not have these conditions in regards to the decrease of ADOS total score after 2 years of EIBI therapy. We found no significant difference between them (p = 0,59). The results are shown in Fig 4.

Another variabile that was taken into account was the intellectual capacity, evaluated through the IQ score. Thirty two of the children (27,6%) had a diagnosis of intellectual disability received from a psychiatrist working the public healthcare system. By splitting the sample into two groups, one with children with intellectual disability and one with children without intellectual disability, we compared the ADOS total score after 2 years of therapy . We found no statistically significant difference between the two groups (p = 0,63). The comparative statistical results for the two groups are shown in Fig 5.

In regards to age, because the age group was small (2-5 year olds), we did not find any statistically significant correlation between the age at intake and the decrease of ADOS total score (p = 0,828).
After 2 years of early intensive behavioral intervention, the ADOS total scores of 97,4% of the children from the sample decreased significantly, and just
2,6% remained unchanged or increased. The presence of comorbid disorders, such as ADHD or hyperkinetic disorder did not significantly influence the progress of children in the recovery process, and neither did intellectual disability or age, which were not associated with a statistically significant increase or decrease of ADOS total scores. The decrease of ADOS total score regardless of other disorders or age signifies a decrease in the severity of ASD symptoms and an improvement of their mental state on many developmental domains.
In our sample, the comorbidities did not influence the therapeutic progress. Also, therapy starting age did not influence the therapeutic progress. This proves the efficiency of EIBI therapies for any category of affected children and encourages the beginning of a therapeutic program independently of the severity of the disease or the associated pathologies.
For a better understanding of the factors that influence the process of recovery through intensive therapy, correlations with other scores from tests that evaluate specific areas in social and cognitive evolution are necessary (for example, ABAS for evaluating adaptive behavior, ASRS, ADI-R, etc).
The authors report no conflict of interest in the development of this research.
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